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ACTUActuate Therapeutics Inc

The Read

Actuate Therapeutics’ stock plunged about 46% on Q4 2025 fears of imminent cash exhaustion and dilution, then surged over 85% on Q2 2026 trial success doubling pancreatic cancer survival and board additions, and rose about 28% after FDA IND clearance offsetting expected dilution.
Nov 8, 2026 — FDA Protocol Agreement & Phase 2 Trial Initiation
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The schedule

  • Sun8Nov

    FDA approval of protocol agreement for Phase 2 trial of lead candidate, accelerating development timelines.

  • Fri13Nov

    Earnings report following Phase 2 trial data release, with guidance on strategic partnerships and pipeline progress.

  • Tue12Jan

    Presentation of clinical data from ASCO highlighting efficacy of lead candidate in high-risk populations.

  • Sun14Feb

    Year-end earnings report with updated guidance on commercialization readiness and trial enrollment.

  • Sun16May
  • Fri13Aug

Past

  • Tue6Oct

    Actual outcome: Bear · $0.46 at outcome

    ACTU experienced a sharp decline due to a significant earnings miss and downward guidance, which exceeded market expectations. The company reported lower-than-expected revenue and profit, with management citing weaker-than-anticipated demand in key markets. This led to a re-rating of the stock, particularly in the ultra-short term. [Market retrospective · Ultra-Short (1–5 days)] Missed anticipation: -20.9% from 2026-10-06 to 2026-10-07 (~2.6σ vs typical 1d vol). Target evaluation date 2026-10-08 (not yet reached as of 2026-10-07). Confidence 95%. [Market retrospective · Ultra-Short (1–5 days)] Updated observation 2026-10-08: -20.9% from 2026-10-06 (~2.6σ). Target date 2026-10-08 reached; move through 2026-10-08 observed. [Market retrospective · Ultra-Short (1–5 days)] Updated observation 2026-10-13: -26.7% from 2026-10-12 (~3.1σ). Target date 2026-10-08 reached; move through 2026-10-13 observed.

    ACTU experienced a sharp decline due to a significant earnings miss and downward guidance, which exceeded market expectations. The company reported lower-than-expected revenue and profit, with management citing weaker-than-anticipated demand in key markets. This led to a re-rating of the stock, particularly in the ultra-short term. [Market retrospective · Ultra-Short (1–5 days)] Missed anticipation: -20.9% from 2026-10-06 to 2026-10-07 (~2.6σ vs typical 1d vol). Target evaluation date 2026-10-08 (not yet reached as of 2026-10-07). Confidence 95%. [Market retrospective · Ultra-Short (1–5 days)] Updated observation 2026-10-08: -20.9% from 2026-10-06 (~2.6σ). Target date 2026-10-08 reached; move through 2026-10-08 observed. [Market retrospective · Ultra-Short (1–5 days)] Updated observation 2026-10-13: -26.7% from 2026-10-12 (~3.1σ). Target date 2026-10-08 reached; move through 2026-10-13 observed.

  • Fri14Aug

    Actual outcome: Mixed · $1.06 at outcome

    ACTU reported Q2 earnings in line with expectations, with an EPS actual of -0.2 versus an estimate of -0.2. The stock rallied 5.0% following the event due to critical mid-stage clinical updates for elraglusib, which signaled progress in the drug's development. The positive clinical data and forward guidance on potential regulatory milestones drove investor confidence, despite the earnings miss.

    Q2 financial results coupled with critical mid-stage clinical updates for elraglusib.

  • Wed15Jul

    Actual outcome: Bear · $1.40 at outcome

    Actuate Therapeutics executed a strategic equity financing to address its precarious cash runway. While the offering provided necessary capital to sustain operations, the resulting equity dilution weighed heavily on shares, driving a 16.3% decline as investors priced in the expanded share count.

    Anticipated capital raise to address the company's precarious cash runway.

  • Mon18May

    Actual outcome: Bull · $2.51 at outcome

    The anticipated dilutive equity financing did not materialize during the event window. Instead, the market focused on the recent FDA clearance of the company's IND application for oral elraglusib, a positive regulatory milestone that allowed the stock to hold steady near the $2.50 bull target without the expected downward pressure from a capital raise.

    The company announces a Registered Direct Offering (RDO) or At-The-Market (ATM) equity raise to fund operations past the Q3 2026 clinical readout. This is necessary due to the short cash runway confirmed in Q4 earnings.

  • Thu26Mar

    Actual outcome: Bear · $2.50 at outcome

    Actuate Therapeutics reported in-line Q4 EPS of -$0.20, but the stock failed to gain traction and fell well below the $3.50 bear floor. Despite announcing a new strategic research initiative to combine Elraglusib with RAS inhibitors just prior to the report, the lack of a meaningful positive catalyst or reassuring financial runway update left investors cautious, driving the stock lower.

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